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The city of LaSalle is located in LaSalle County, Illinois, at the intersection of Interstate 80 and Interstate 39. It is part of the Ottawa–Streator Micropolitan Statistical Area. Originally platted in 1837 over one square mile, the city has grown to 12 square miles (31 km2).
City boundaries extend from the Illinois River and Illinois and Michigan Canal to a mile north of Interstate 80 and from the city of Peru on the west to the village of North Utica on the east.